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Probable human origin of the SARS-CoV-2 polybasic furin cleavage motif
BACKGROUND: The key evolutionary step leading to the pandemic virus was the acquisition of the PRRA furin cleavage motif at the spike glycoprotein S1/S2 junction by a progenitor of SARS-CoV-2. Two of its features draw attention: (i) it is absent in other known lineage B beta-coronaviruses, including...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664542/ https://www.ncbi.nlm.nih.gov/pubmed/37990144 http://dx.doi.org/10.1186/s12863-023-01169-8 |