Identification of non-conventional small molecule degraders and stabilizers of squalene synthase

Squalene synthase (SQS) is an essential enzyme in the mevalonate pathway, which controls cholesterol biosynthesis and homeostasis. Although catalytic inhibitors of SQS have been developed, none have been approved for therapeutic use so far. Herein we sought to develop SQS degraders using targeted pr...

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Detalles Bibliográficos
Autores principales: Hoock, Joseph G. F., Rossetti, Cecilia, Bilgin, Mesut, Depta, Laura, Enemark-Rasmussen, Kasper, Christianson, John C., Laraia, Luca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664564/
https://www.ncbi.nlm.nih.gov/pubmed/38023519
http://dx.doi.org/10.1039/d3sc04064j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664564/
https://www.ncbi.nlm.nih.gov/pubmed/38023519
http://dx.doi.org/10.1039/d3sc04064j

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