An essential role for miR-15/16 in Treg suppression and restriction of proliferation

The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells to mediate a sustained response. Here, we used conditional d...

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Detalles Bibliográficos
Autores principales: Johansson, Kristina, Gagnon, John D., Zhou, Simon K., Fassett, Marlys S., Schroeder, Andrew W., Kageyama, Robin, Bautista, Rodriel A., Pham, Hewlett, Woodruff, Prescott G., Ansel, K. Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664750/
https://www.ncbi.nlm.nih.gov/pubmed/37862171
http://dx.doi.org/10.1016/j.celrep.2023.113298

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664750/
https://www.ncbi.nlm.nih.gov/pubmed/37862171
http://dx.doi.org/10.1016/j.celrep.2023.113298

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