Therapeutic targeting of CPSF3-dependent transcriptional termination in ovarian cancer

Transcriptional dysregulation is a recurring pathogenic hallmark and an emerging therapeutic vulnerability in ovarian cancer. Here, we demonstrated that ovarian cancer exhibited a unique dependency on the regulatory machinery of transcriptional termination, particularly, cleavage and polyadenylation...

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Detalles Bibliográficos
Autores principales: Shen, Peiye, Ye, Kaiyan, Xiang, Huaijiang, Zhang, Zhenfeng, He, Qinyang, Zhang, Xiao, Cai, Mei-Chun, Chen, Junfei, Sun, Yunheng, Lin, Lifeng, Qi, Chunting, Zhang, Meiying, Cheung, Lydia W. T., Shi, Tingyan, Yin, Xia, Li, Ying, Di, Wen, Zang, Rongyu, Tan, Li, Zhuang, Guanglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664987/
https://www.ncbi.nlm.nih.gov/pubmed/37992178
http://dx.doi.org/10.1126/sciadv.adj0123

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664987/
https://www.ncbi.nlm.nih.gov/pubmed/37992178
http://dx.doi.org/10.1126/sciadv.adj0123

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