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Macrophage activation drives ovarian failure and masculinization in zebrafish

BMP15 is a conserved regulator of ovarian development and maintenance in vertebrates. In humans, premature ovarian insufficiency is caused by autoimmunity and genetic factors, including mutation of BMP15. The cellular mechanisms underlying ovarian failure caused by BMP15 mutation and immune contribu...

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Detalles Bibliográficos
Autores principales: Bravo, Paloma, Liu, Yulong, Draper, Bruce W., Marlow, Florence L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664988/
https://www.ncbi.nlm.nih.gov/pubmed/37992158
http://dx.doi.org/10.1126/sciadv.adg7488