Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Huntington’s disease (HD) is a neurodegenerative disorder caused by a dominantly inherited CAG repeat expansion in the huntingtin gene (HTT). Neuroinflammation and microglia have been implicated in HD pathology, however it has been unclear if mutant HTT (mHTT) expression has an adverse cell-autonomo...

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Detalles Bibliográficos
Autores principales: Stöberl, Nina, Donaldson, Jasmine, Binda, Caroline S., McAllister, Branduff, Hall-Roberts, Hazel, Jones, Lesley, Massey, Thomas H., Allen, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665390/
https://www.ncbi.nlm.nih.gov/pubmed/37993517
http://dx.doi.org/10.1038/s41598-023-46852-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665390/
https://www.ncbi.nlm.nih.gov/pubmed/37993517
http://dx.doi.org/10.1038/s41598-023-46852-z

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