Cargando…

Mutant huntingtin confers cell-autonomous phenotypes on Huntington’s disease iPSC-derived microglia

Huntington’s disease (HD) is a neurodegenerative disorder caused by a dominantly inherited CAG repeat expansion in the huntingtin gene (HTT). Neuroinflammation and microglia have been implicated in HD pathology, however it has been unclear if mutant HTT (mHTT) expression has an adverse cell-autonomo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Stöberl, Nina, Donaldson, Jasmine, Binda, Caroline S., McAllister, Branduff, Hall-Roberts, Hazel, Jones, Lesley, Massey, Thomas H., Allen, Nicholas D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665390/ https://www.ncbi.nlm.nih.gov/pubmed/37993517 http://dx.doi.org/10.1038/s41598-023-46852-z

Ejemplares similares

Human iPSC-derived glia models for the study of neuroinflammation
por: Stöberl, Nina, et al.
Publicado: (2023)

Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation
por: Cariulo, Cristina, et al.
Publicado: (2017)

Timing and Impact of Psychiatric, Cognitive, and Motor Abnormalities in Huntington Disease
por: McAllister, Branduff, et al.
Publicado: (2021)

Huntington's disease cerebrospinal fluid seeds aggregation of mutant huntingtin
por: Tan, Z, et al.
Publicado: (2015)

Innate immune activation and aberrant function in the R6/2 mouse model and Huntington’s disease iPSC-derived microglia
por: Gasser, Julien, et al.
Publicado: (2023)

Huntington’s Disease: From Mutant Huntingtin Protein to Neurotrophic Factor Therapy
por: Sari, Youssef
Publicado: (2011)

Embryonic Mutant Huntingtin Aggregate Formation in Mouse Models of Huntington’s Disease
por: Osmand, Alexander P., et al.
Publicado: (2016)

Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
por: Fodale, Valentina, et al.
Publicado: (2020)

Soluble mutant huntingtin drives early human pathogenesis in Huntington’s disease
por: Miguez, Andrés, et al.
Publicado: (2023)

Mutant Huntingtin Does Not Affect the Intrinsic Phenotype of Human Huntington’s Disease T Lymphocytes
por: Miller, James R. C., et al.
Publicado: (2015)

Genistein induces degradation of mutant huntingtin in fibroblasts from Huntington’s disease patients
por: Pierzynowska, Karolina, et al.
Publicado: (2019)

Assaying Microglia Functions In Vitro
por: Maguire, Emily, et al.
Publicado: (2022)

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons
por: Beatriz, Margarida, et al.
Publicado: (2023)

Synaptic and functional alterations in the development of mutant huntingtin expressing hiPSC‐derived neurons
por: Dinamarca, Margarita C., et al.
Publicado: (2022)

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
por: Abreu, Celina Monteiro, et al.
Publicado: (2018)

Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models
por: Hedegaard, Anne, et al.
Publicado: (2020)

Microglia Influence Neurofilament Deposition in ALS iPSC-Derived Motor Neurons
por: Allison, Reilly L., et al.
Publicado: (2022)

Neuronal Targets of Mutant Huntingtin Genetic Reduction to Ameliorate Huntington’s Disease Pathogenesis in Mice
por: Wang, Nan, et al.
Publicado: (2014)

Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease
por: Ehrnhoefer, Dagmar E., et al.
Publicado: (2018)

Mutant Huntingtin Affects Diabetes and Alzheimer’s Markers in Human and Cell Models of Huntington’s Disease
por: Chaves, Gepoliano, et al.
Publicado: (2019)

Transglutaminase 6 Is Colocalized and Interacts with Mutant Huntingtin in Huntington Disease Rodent Animal Models
por: Schulze-Krebs, Anja, et al.
Publicado: (2021)

Esculetin Provides Neuroprotection against Mutant Huntingtin-Induced Toxicity in Huntington’s Disease Models
por: Pruccoli, Letizia, et al.
Publicado: (2021)

Effects of mutant huntingtin inactivation on Huntington disease‐related behaviours in the BACHD mouse model
por: Cheong, Rachel Y., et al.
Publicado: (2021)

Amelioration of Huntington’s disease phenotype in astrocytes derived from iPSC-derived neural progenitor cells of Huntington’s disease monkeys
por: Cho, In Ki, et al.
Publicado: (2019)

Bioenergetic deficits in Huntington’s disease iPSC-derived neural cells and rescue with glycolytic metabolites
Publicado: (2020)

Characterization of Neurodevelopmental Abnormalities in iPSC-Derived Striatal Cultures from Patients with Huntington’s Disease
por: Mathkar, Pranav P., et al.
Publicado: (2019)

Brain microvascular endothelial cell dysfunction in an isogenic juvenile iPSC model of Huntington’s disease
por: Linville, Raleigh M., et al.
Publicado: (2022)

Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
por: Banerjee, Poulomi, et al.
Publicado: (2023)

iPSC-Derived Microglia as a Model to Study Inflammation in Idiopathic Parkinson’s Disease
por: Badanjak, Katja, et al.
Publicado: (2021)

Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models
por: Yu, Meng, et al.
Publicado: (2017)

Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington’s disease
por: Niu, Li, et al.
Publicado: (2018)

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington's disease models
por: Hegde, Ramanath Narayana, et al.
Publicado: (2020)

Osmolytes dynamically regulate mutant Huntingtin aggregation and CREB function in Huntington’s disease cell models
por: Aravindan, Shreyaas, et al.
Publicado: (2020)

Phenotype onset in Huntington’s disease knock‐in mice is correlated with the incomplete splicing of the mutant huntingtin gene
por: Franich, Nicholas R., et al.
Publicado: (2019)

Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
por: Eshraghi, Mehdi, et al.
Publicado: (2021)

Mutant Huntingtin Derails Cysteine Metabolism in Huntington’s Disease at Both Transcriptional and Post-Translational Levels
por: Paul, Bindu D., et al.
Publicado: (2022)

Integrative determination of the atomic structure of mutant huntingtin exon 1 fibrils from Huntington’s disease
por: Helabad, Mahdi Bagherpoor, et al.
Publicado: (2023)

Huntingtin Aggregates in the Olfactory Bulb in Huntington’s Disease
por: Highet, Blake, et al.
Publicado: (2020)

Emerging Therapies for Huntington’s Disease – Focus on N-Terminal Huntingtin and Huntingtin Exon 1
por: van der Bent, M Leontien, et al.
Publicado: (2022)

Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology
por: Zhao, Chen, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_kia3h1iq5nr1sroiel0ahjoe1j