Cargando…

Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection

Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lin, Jake, Moradi, Elaheh, Salenius, Karoliina, Lehtipuro, Suvi, Häkkinen, Tomi, Laiho, Jutta E., Oikarinen, Sami, Randelin, Sofia, Parikh, Hemang M., Krischer, Jeffrey P., Toppari, Jorma, Lernmark, Åke, Petrosino, Joseph F., Ajami, Nadim J., She, Jin-Xiong, Hagopian, William A., Rewers, Marian J., Lloyd, Richard E., Rautajoki, Kirsi J., Hyöty, Heikki, Nykter, Matti
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665402/ https://www.ncbi.nlm.nih.gov/pubmed/37993433 http://dx.doi.org/10.1038/s41467-023-42763-9

Ejemplares similares

Modes of immunosuppression in glioblastoma microenvironment
por: Lehtipuro, Suvi, et al.
Publicado: (2019)

Metagenomics of the faecal virome indicate a cumulative effect of enterovirus and gluten amount on the risk of coeliac disease autoimmunity in genetically at risk children: the TEDDY study
por: Lindfors, Katri, et al.
Publicado: (2020)

Enterovirus Infections Are Associated With the Development of Celiac Disease in a Birth Cohort Study
por: Oikarinen, Maarit, et al.
Publicado: (2021)

Differential Detection of Encapsidated versus Unencapsidated Enterovirus RNA in Samples Containing Pancreatic Enzymes—Relevance for Diabetes Studies
por: Oikarinen, Maarit, et al.
Publicado: (2020)

Detection of Viral −RNA and +RNA Strands in Enterovirus-Infected Cells and Tissues
por: Salmikangas, Sami, et al.
Publicado: (2020)

Prospective virome analyses in young children at increased genetic risk for type 1 diabetes
por: Vehik, Kendra, et al.
Publicado: (2019)

Type 1 Diabetes Is Associated With Enterovirus Infection in Gut Mucosa
por: Oikarinen, Maarit, et al.
Publicado: (2012)

Maternal Enterovirus Infection during Pregnancy as a Risk Factor in Offspring Diagnosed with Type 1 Diabetes between 15 and 30 Years of Age
por: Elfving, Maria, et al.
Publicado: (2008)

Characterisation of enterovirus RNA detected in the pancreas and other specimens of live patients with newly diagnosed type 1 diabetes in the DiViD study
por: Oikarinen, Sami, et al.
Publicado: (2021)

Enterovirus Infection and Progression From Islet Autoimmunity to Type 1 Diabetes: The Diabetes and Autoimmunity Study in the Young (DAISY)
por: Stene, Lars C., et al.
Publicado: (2010)

Temporal changes in gastrointestinal fungi and the risk of autoimmunity during early childhood: the TEDDY study
por: Auchtung, Thomas A., et al.
Publicado: (2022)

Enterovirus-associated changes in blood transcriptomic profiles of children with genetic susceptibility to type 1 diabetes
por: Lietzen, Niina, et al.
Publicado: (2017)

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study
por: Li, Qian, et al.
Publicado: (2020)

SARS-CoV-2 — No Increased Islet Autoimmunity or Type 1 Diabetes in Teens
por: Krischer, Jeffrey P., et al.
Publicado: (2023)

Enterovirus RNA in Blood Is Linked to the Development of Type 1 Diabetes
por: Oikarinen, Sami, et al.
Publicado: (2011)

Plasma ascorbic acid and the risk of islet autoimmunity and type 1 diabetes: the TEDDY study
por: Mattila, Markus, et al.
Publicado: (2019)

Molecular epidemiology of enteroviruses in young children at increased risk of type 1 diabetes
por: Sioofy-Khojine, Amir-Babak, et al.
Publicado: (2018)

Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
por: Elding Larsson, Helena, et al.
Publicado: (2017)

The human gut microbiome in early-onset type 1 diabetes from the TEDDY study
por: Vatanen, Tommi, et al.
Publicado: (2018)

The Influence of Type 1 Diabetes Genetic Susceptibility Regions, Age, Sex, and Family History on the Progression From Multiple Autoantibodies to Type 1 Diabetes: A TEDDY Study Report
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Assessment of Enterovirus Antibodies during Early Childhood Using a Multiplex Immunoassay
por: Jouppila, N. V. V., et al.
Publicado: (2023)

Genetic and Environmental Interactions Modify the Risk of Diabetes-Related Autoimmunity by 6 Years of Age: The TEDDY Study
por: Krischer, Jeffrey P., et al.
Publicado: (2017)

Temporal development of the gut microbiome in early childhood from the TEDDY study
por: Stewart, Christopher J., et al.
Publicado: (2018)

Early-onset grade 2-3 diffuse gliomas and schwannomas increase the risk of central nervous system tumors among the patients’ relatives
por: Alanen, Eljas, et al.
Publicado: (2023)

A method for reporting and classifying acute infectious diseases in a prospective study of young children: TEDDY
por: Lönnrot, Maria, et al.
Publicado: (2015)

Immunomodulatory Effects of Rhinovirus and Enterovirus Infections During the First Year of Life
por: Ruohtula, Terhi, et al.
Publicado: (2021)

Genetic Adaptation of Coxsackievirus B1 during Persistent Infection in Pancreatic Cells
por: Honkimaa, Anni, et al.
Publicado: (2020)

Coxsackievirus B Persistence Modifies the Proteome and the Secretome of Pancreatic Ductal Cells
por: Lietzén, Niina, et al.
Publicado: (2019)

Growth and Risk for Islet Autoimmunity and Progression to Type 1 Diabetes in Early Childhood: The Environmental Determinants of Diabetes in the Young Study
por: Elding Larsson, Helena, et al.
Publicado: (2016)

Children’s erythrocyte fatty acids are associated with the risk of islet autoimmunity
por: Niinistö, Sari, et al.
Publicado: (2021)

HbA1c as a time predictive biomarker for an additional islet autoantibody and type 1 diabetes in seroconverted TEDDY children
por: Salami, Falastin, et al.
Publicado: (2022)

Successful collection of stool samples for microbiome analyses from a large community-based population of elderly men
por: Abrahamson, Melanie, et al.
Publicado: (2017)

Prostate‐specific membrane antigen expression in the vasculature of primary lung carcinomas associates with faster metastatic dissemination to the brain
por: Tanjore Ramanathan, Jayendrakishore, et al.
Publicado: (2020)

Early Infant Diet and Islet Autoimmunity in the TEDDY Study
por: Uusitalo, Ulla, et al.
Publicado: (2018)

Detection and localization of viral infection in the pancreas of patients with type 1 diabetes using short fluorescently-labelled oligonucleotide probes
por: Busse, Niels, et al.
Publicado: (2017)

Metabolite-related dietary patterns and the development of islet autoimmunity
por: Johnson, Randi K., et al.
Publicado: (2019)

Maximal viral information recovery from sequence data using VirMAP
por: Ajami, Nadim J, et al.
Publicado: (2018)

Progression from islet autoimmunity to clinical type 1 diabetes is influenced by genetic factors: results from the prospective TEDDY study
por: Beyerlein, Andreas, et al.
Publicado: (2019)

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study
por: Törn, Carina, et al.
Publicado: (2022)

Multiplexed High-Throughput Serological Assay for Human Enteroviruses
por: Saarinen, Niila V. V., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_nhvt4jve16sfu4tk9rhnmbc016