Reduced LHFPL3-AS2 lncRNA expression is linked to altered epithelial polarity and proliferation, and to ileal ulceration in Crohn disease

Disruption of intestinal epithelial functions is linked to Crohn disease (CD) pathogenesis. We identified a widespread reduction in the expression of long non-coding RNAs (lncRNAs) including LHFPL3-AS2 in the treatment-naïve CD ileum of the RISK pediatric cohort. We validated the reduction of LHFPL3...

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Detalles Bibliográficos
Autores principales: Sosnovski, Katya E., Braun, Tzipi, Amir, Amnon, BenShoshan, Marina, Abbas-Egbariya, Haya, Ben-Yishay, Rakefet, Anafi, Liat, Avivi, Camilla, Barshack, Iris, Denson, Lee A., Haberman, Yael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665440/
https://www.ncbi.nlm.nih.gov/pubmed/37993670
http://dx.doi.org/10.1038/s41598-023-47997-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665440/
https://www.ncbi.nlm.nih.gov/pubmed/37993670
http://dx.doi.org/10.1038/s41598-023-47997-7

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