A distinct topology of BTN3A IgV and B30.2 domains controlled by juxtamembrane regions favors optimal human γδ T cell phosphoantigen sensing

Butyrophilin (BTN)–3A and BTN2A1 molecules control the activation of human Vγ9Vδ2 T cells during T cell receptor (TCR)-mediated sensing of phosphoantigens (PAg) derived from microbes and tumors. However, the molecular rules governing PAg sensing remain largely unknown. Here, we establish three mecha...

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Detalles Bibliográficos
Autores principales: Karunakaran, Mohindar M., Subramanian, Hariharan, Jin, Yiming, Mohammed, Fiyaz, Kimmel, Brigitte, Juraske, Claudia, Starick, Lisa, Nöhren, Anna, Länder, Nora, Willcox, Carrie R., Singh, Rohit, Schamel, Wolfgang W., Nikolaev, Viacheslav O., Kunzmann, Volker, Wiemer, Andrew J., Willcox, Benjamin E., Herrmann, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665462/
https://www.ncbi.nlm.nih.gov/pubmed/37993425
http://dx.doi.org/10.1038/s41467-023-41938-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665462/
https://www.ncbi.nlm.nih.gov/pubmed/37993425
http://dx.doi.org/10.1038/s41467-023-41938-8

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