Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS

BACKGROUND: Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole, voriconazole, isavuconazole and posaconazole) when or...

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Detalles Bibliográficos
Autores principales: Xia, Mengming, Song, Xueyi, Lu, Zebei, Wang, Yu, Zhou, Quan, Geng, Peiwu, Wang, Shuanghu, Zhou, Yunfang, Wu, Qingjun, Han, Aixia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons Australia, Ltd 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665782/
https://www.ncbi.nlm.nih.gov/pubmed/37771131
http://dx.doi.org/10.1111/1759-7714.15125

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665782/
https://www.ncbi.nlm.nih.gov/pubmed/37771131
http://dx.doi.org/10.1111/1759-7714.15125

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