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Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis

The ubiquitin-proteasome system (UPS) governs the degradation of proteins by ubiquitinating their lysine residues. Our study focuses on lysine deserts - regions in proteins conspicuously low in lysine residues – in averting ubiquitin-dependent proteolysis. We spotlight the prevalence of lysine deser...

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Detalles Bibliográficos
Autores principales: Szulc, Natalia A., Piechota, Małgorzata, Biriczová, Lilla, Thapa, Pankaj, Pokrzywa, Wojciech
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665810/
https://www.ncbi.nlm.nih.gov/pubmed/38026164
http://dx.doi.org/10.1016/j.isci.2023.108344