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Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis
The ubiquitin-proteasome system (UPS) governs the degradation of proteins by ubiquitinating their lysine residues. Our study focuses on lysine deserts - regions in proteins conspicuously low in lysine residues – in averting ubiquitin-dependent proteolysis. We spotlight the prevalence of lysine deser...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665810/ https://www.ncbi.nlm.nih.gov/pubmed/38026164 http://dx.doi.org/10.1016/j.isci.2023.108344 |