Cargando…

IFNγ and CTLA-4 Drive Hepatic CD4 T-Cell Tolerance and Protection From Autoimmunity in Mice

BACKGROUND & AIMS: The liver has a distinct capacity to induce immune tolerance to hepatic antigens. Although liver tolerance can be advantageous for preventing autoimmune and inflammatory diseases, it also can be detrimental by preventing immune surveillance of infected or malignant cells. Here...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krzikalla, Daria, Laschtowitz, Alena, Leypoldt, Lisa, Gottwick, Cornelia, Averhoff, Pia, Weidemann, Sören, Lohse, Ansgar W., Huber, Samuel, Schramm, Christoph, Schwinge, Dorothee, Herkel, Johannes, Carambia, Antonella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665921/ https://www.ncbi.nlm.nih.gov/pubmed/37734595 http://dx.doi.org/10.1016/j.jcmgh.2023.09.006

Ejemplares similares

Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver
por: Preti, Max, et al.
Publicado: (2021)

Harnessing the liver to induce antigen-specific immune tolerance
por: Gottwick, Cornelia, et al.
Publicado: (2022)

Nanoparticle‐mediated targeting of autoantigen peptide to cross‐presenting liver sinusoidal endothelial cells protects from CD8 T‐cell‐driven autoimmune cholangitis
por: Carambia, Antonella, et al.
Publicado: (2021)

CD4+ T-Cell Help Is Required for Effective CD8+ T Cell-Mediated Resolution of Acute Viral Hepatitis in Mice
por: Trautmann, Tanja, et al.
Publicado: (2014)

Aryl Hydrocarbon Receptor Activity in Hepatocytes Sensitizes to Hyperacute Acetaminophen-Induced Hepatotoxicity in Mice
por: Schuran, Fenja A., et al.
Publicado: (2020)

Lupus susceptibility region containing CTLA4 rs17268364 functionally reduces CTLA4 expression by binding EWSR1 and correlates IFN-α signature
por: Qi, Yuan-yuan, et al.
Publicado: (2021)

Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis
por: Sebode, Marcial, et al.
Publicado: (2019)

Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production
por: Watari, Kei, et al.
Publicado: (2019)

The Effects of Androgens on T Cells: Clues to Female Predominance in Autoimmune Liver Diseases?
por: Henze, Lara, et al.
Publicado: (2020)

Increased concentrations of conjugated bile acids are associated with osteoporosis in PSC patients
por: Stürznickel, Julian, et al.
Publicado: (2022)

Histological activity despite normal ALT and IgG serum levels in patients with autoimmune hepatitis and cirrhosis
por: Laschtowitz, Alena, et al.
Publicado: (2021)

CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma
por: Hoffmann, Friederike, et al.
Publicado: (2023)

Accuracy of controlled attenuation parameter measurement for the detection of steatosis in autoimmune liver diseases
por: Steinmann, Silja, et al.
Publicado: (2023)

Lack of association between sCTLA-4 levels in human plasma and common CTLA-4 polymorphisms
por: Berry, Andrew, et al.
Publicado: (2008)

CTLA-4: From conflict to clinic
por: Bashyam, Hema
Publicado: (2007)

The role of CTLA-4 in immune regulation
por: Verhagen, Johan, et al.
Publicado: (2008)

Activated CTLA‐4‐independent immunosuppression of Treg cells disturbs CTLA‐4 blockade‐mediated antitumor immunity
por: Watanabe, Tomofumi, et al.
Publicado: (2023)

Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry
por: Rojas-Restrepo, Jessica, et al.
Publicado: (2023)

P38 MAP Kinase Signaling Is Required for the Conversion of CD4+CD25− T Cells into iTreg
por: Huber, Samuel, et al.
Publicado: (2008)

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies
por: Peggs, Karl S., et al.
Publicado: (2009)

CTLA-4 Insufficiency due to a Novel CTLA-4 Deletion, Identified through Copy Number Variation Analysis
por: Olfe, Lisa, et al.
Publicado: (2022)

Correction to: Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4‑Dependent Transendocytosis by Flow Cytometry
por: Rojas‑Restrepo, Jessica, et al.
Publicado: (2023)

Pathogen detection in RNA-seq data with Pathonoia
por: Liebhoff, Anna-Maria, et al.
Publicado: (2023)

CTLA4 polymorphism and primary Sjögren's syndrome
por: Lester, Susan, et al.
Publicado: (2007)

CTLA-4 based therapy (MDX-010)
por: Korman, A
Publicado: (2003)

CTLA-4 and Autoimmunity: New Twists in the Tale
por: Walker, Lucy S.K.
Publicado: (2015)

Effects of CTLA4-Ig on human monocytes
por: Tono, Toshihiro, et al.
Publicado: (2017)

CTLA-4 in Regulatory T Cells for Cancer Immunotherapy
por: Sobhani, Navid, et al.
Publicado: (2021)

Blood PD-1(+)TFh and CTLA-4(+)CD4(+) T cells predict remission after CTLA-4Ig treatment in early rheumatoid arthritis
por: Aldridge, Jonathan, et al.
Publicado: (2021)

Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy
por: Shi, Lewis Zhichang, et al.
Publicado: (2016)

(64)Cu-DOTA-Anti-CTLA-4 mAb Enabled PET Visualization of CTLA-4 on the T-Cell Infiltrating Tumor Tissues
por: Higashikawa, Kei, et al.
Publicado: (2014)

Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice
por: Du, Xuexiang, et al.
Publicado: (2018)

TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma
por: Khanolkar, Rahul C., et al.
Publicado: (2022)

CTLA-4 CT-60 A/G and CTLA-4 1822 C/T Gene Polymorphisms in Indonesians with Type 1 Diabetes Mellitus
por: Rochmah, Nur, et al.
Publicado: (2022)

Attenuated viral hepatitis in Trem1−/− mice is associated with reduced inflammatory activity of neutrophils
por: Kozik, Jan-Hendrik, et al.
Publicado: (2016)

Single-cell atlas of hepatic T cells reveals expansion of liver-resident naive-like CD4(+) T cells in primary sclerosing cholangitis
por: Poch, Tobias, et al.
Publicado: (2021)

CTLA-4: a negative regulator of autoimmune disease
Publicado: (1996)

CTLA-4 blockade: therapeutic potential in cancer treatments
por: Tarhini, Ahmad A, et al.
Publicado: (2010)

Comparison of the Intracellular Trafficking Itinerary of CTLA-4 Orthologues
por: Kaur, Satdip, et al.
Publicado: (2013)

Confusing signals: Recent progress in CTLA-4 biology
por: Walker, Lucy S.K., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_bqd8p599oer78a2pdk7mmf1ve4