Hepatocyte FoxO1 Deficiency Protects From Liver Fibrosis via Reducing Inflammation and TGF-β1-mediated HSC Activation

BACKGROUND & AIMS: The O-class of the forkhead transcription factor FoxO1 is a crucial factor mediating insulin→PI3K→Akt signaling and governs diverse cellular processes. However, the role of hepatocyte FoxO1 in liver fibrosis has not been well-established. In his study, we investigated the role...

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Detalles Bibliográficos
Autores principales: Pan, Quan, Gao, Mingming, Kim, DaMi, Ai, Weiqi, Yang, Wanbao, Jiang, Wen, Brashear, Wesley, Dai, Yujiao, Li, Sha, Sun, Yuxiang, Qi, Yajuan, Guo, Shaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665954/
https://www.ncbi.nlm.nih.gov/pubmed/37678798
http://dx.doi.org/10.1016/j.jcmgh.2023.08.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665954/
https://www.ncbi.nlm.nih.gov/pubmed/37678798
http://dx.doi.org/10.1016/j.jcmgh.2023.08.013

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