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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

Zoonotic arenavirus infections can result in viral hemorrhagic disease, characterized by platelet loss, petechia, and multi-organ injury. The mechanisms governing these outcomes are likely impacted by virus strain and infection dose, as well as an individual’s genetic background and immune constitut...

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Detalles Bibliográficos
Autores principales: Tibbs, Taylor N., Donoghue, Lauren J., Buzzelli, Ashlyn A., Misumi, Ichiro, DeMonia, Maggie, Ferris, Martin T., Kelada, Samir N.P., Whitmire, Jason K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10665959/
https://www.ncbi.nlm.nih.gov/pubmed/38026197
http://dx.doi.org/10.1016/j.isci.2023.108348