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FOXO inhibition rescues α-defensin expression in human intestinal organoids
To mediate critical host–microbe interactions in the human small intestine, Paneth cells constitutively produce abundant levels of α-defensins and other antimicrobials. We report that the expression profile of these antimicrobials is dramatically askew in human small intestinal organoids (enteroids)...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666032/ https://www.ncbi.nlm.nih.gov/pubmed/37956278 http://dx.doi.org/10.1073/pnas.2312453120 |