Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations

In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR) channel lead to an acidic airway surface liquid (ASL), which compromises innate defence mechanisms, predisposing to pulmonary failure. Restoring ASL pH is a potential therapy for people with CF, particularly for th...

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Detalles Bibliográficos
Autores principales: Delpiano, Livia, Rodenburg, Lisa W., Burke, Matthew, Nelson, Glyn, Amatngalim, Gimano D., Beekman, Jeffrey M., Gray, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666107/
https://www.ncbi.nlm.nih.gov/pubmed/37967223
http://dx.doi.org/10.1073/pnas.2307551120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666107/
https://www.ncbi.nlm.nih.gov/pubmed/37967223
http://dx.doi.org/10.1073/pnas.2307551120

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