Cargando…

Dynamic regulation of airway surface liquid pH by TMEM16A and SLC26A4 in cystic fibrosis nasal epithelia with rare mutations

In cystic fibrosis (CF), defects in the CF transmembrane conductance regulator (CFTR) channel lead to an acidic airway surface liquid (ASL), which compromises innate defence mechanisms, predisposing to pulmonary failure. Restoring ASL pH is a potential therapy for people with CF, particularly for th...

Descripción completa

Detalles Bibliográficos
Autores principales:	Delpiano, Livia, Rodenburg, Lisa W., Burke, Matthew, Nelson, Glyn, Amatngalim, Gimano D., Beekman, Jeffrey M., Gray, Michael A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2023
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666107/ https://www.ncbi.nlm.nih.gov/pubmed/37967223 http://dx.doi.org/10.1073/pnas.2307551120

Ejemplares similares

Exploring intrinsic variability between cultured nasal and bronchial epithelia in cystic fibrosis
por: Rodenburg, Lisa W., et al.
Publicado: (2023)

Protocol for generating airway organoids from 2D air liquid interface-differentiated nasal epithelia for use in a functional CFTR assay
por: Rodenburg, Lisa W., et al.
Publicado: (2023)

Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia
por: Amatngalim, Gimano D, et al.
Publicado: (2022)

Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids
por: Rodenburg, Lisa W., et al.
Publicado: (2022)

The Application of Bicarbonate Recovers the Chemical-Physical Properties of Airway Surface Liquid in Cystic Fibrosis Epithelia Models
por: Ferrera, Loretta, et al.
Publicado: (2021)

In vitro Methods for the Development and Analysis of Human Primary Airway Epithelia
por: Gianotti, Ambra, et al.
Publicado: (2018)

Small Molecule Anion Carriers Correct Abnormal Airway Surface Liquid Properties in Cystic Fibrosis Airway Epithelia
por: Gianotti, Ambra, et al.
Publicado: (2020)

Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease
por: Amatngalim, Gimano D., et al.
Publicado: (2018)

Esomeprazole Increases Airway Surface Liquid pH in Primary Cystic Fibrosis Epithelial Cells
por: Delpiano, Livia, et al.
Publicado: (2018)

WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia
por: Rehman, Tayyab, et al.
Publicado: (2022)

Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH
por: Thornell, Ian M., et al.
Publicado: (2020)

Inhibition of the sodium-dependent HCO(3)(-) transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype
por: Saint-Criq, Vinciane, et al.
Publicado: (2022)

Airway Epithelia
por: Johnson, Larry G., et al.
Publicado: (2003)

Small molecule ion channels increase host defenses in cystic fibrosis airway epithelia
por: Muraglia, Katrina A., et al.
Publicado: (2019)

Polarized Signaling via Purinoceptors in Normal and Cystic Fibrosis Airway Epithelia
por: Paradiso, Anthony M., et al.
Publicado: (2001)

Proinflammatory cytokine secretion is suppressed by TMEM16A or CFTR channel activity in human cystic fibrosis bronchial epithelia
por: Veit, Guido, et al.
Publicado: (2012)

Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia
por: Krick, Stefanie, et al.
Publicado: (2017)

Abnormal localization of cystic fibrosis transmembrane conductance regulator in primary cultures of cystic fibrosis airway epithelia
Publicado: (1992)

Cystic fibrosis gene modifier SLC26A9 modulates airway response to CFTR-directed therapeutics
por: Strug, Lisa J., et al.
Publicado: (2016)

Modulator Combination Improves In Vitro the Microrheological Properties of the Airway Surface Liquid of Cystic Fibrosis Airway Epithelia
por: Ludovico, Alessandra, et al.
Publicado: (2022)

Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia
por: Pizzorno, Andrés, et al.
Publicado: (2020)

SLC26A9 is a constitutively active, CFTR-regulated anion conductance in human bronchial epithelia
por: Bertrand, Carol A., et al.
Publicado: (2009)

Choice of Differentiation Media Significantly Impacts Cell Lineage and Response to CFTR Modulators in Fully Differentiated Primary Cultures of Cystic Fibrosis Human Airway Epithelial Cells
por: Saint-Criq, Vinciane, et al.
Publicado: (2020)

Soluble Mediators, Not Cilia, Determine Airway Surface Liquid Volume in Normal and Cystic Fibrosis Superficial Airway Epithelia
por: Tarran, Robert, et al.
Publicado: (2006)

SLC26A9 in airways and intestine: secretion or absorption?
por: Kunzelmann, Karl, et al.
Publicado: (2023)

CK2 is a key regulator of SLC4A2-mediated Cl(−)/HCO(3)(−) exchange in human airway epithelia
por: Ibrahim, Salam H., et al.
Publicado: (2017)

TMEM16A: An Alternative Approach to Restoring Airway Anion Secretion in Cystic Fibrosis?
por: Danahay, Henry, et al.
Publicado: (2020)

Cigarette Smoke Modulates Repair and Innate Immunity following Injury to Airway Epithelial Cells
por: Amatngalim, Gimano D., et al.
Publicado: (2016)

Synergy in Cystic Fibrosis Therapies: Targeting SLC26A9
por: Pinto, Madalena C., et al.
Publicado: (2021)

TNF-α and IL-1β-activated human mesenchymal stromal cells increase airway epithelial wound healing in vitro via activation of the epidermal growth factor receptor
por: Broekman, Winifred, et al.
Publicado: (2016)

Hypercapnia modulates cAMP signalling and cystic fibrosis transmembrane conductance regulator‐dependent anion and fluid secretion in airway epithelia
por: Turner, Mark J., et al.
Publicado: (2015)

Effect of apical chloride concentration on the measurement of responses to CFTR modulation in airway epithelia cultured from nasal brushings
por: Bratcher, Preston E., et al.
Publicado: (2020)

Expression of SLC26A9 in Airways and Its Potential Role in Asthma
por: Ousingsawat, Jiraporn, et al.
Publicado: (2022)

Assisting PNA transport through cystic fibrosis human airway epithelia with biodegradable hybrid lipid-polymer nanoparticles
por: Comegna, Marika, et al.
Publicado: (2021)

Hypoxia Increases Epithelial Permeability in Human Nasal Epithelia
por: Min, Hyun Jin, et al.
Publicado: (2015)

Synchronized roles of pannexin and connexin in nasal mucosal epithelia
por: Ohbuchi, Toyoaki, et al.
Publicado: (2018)

Development of the Olfactory Epithelium and Nasal Glands in TMEM16A(-/-) and TMEM16A(+/+) Mice
por: Maurya, Devendra Kumar, et al.
Publicado: (2015)

Lipoxin A(4) Stimulates Calcium-Activated Chloride Currents and Increases Airway Surface Liquid Height in Normal and Cystic Fibrosis Airway Epithelia
por: Verrière, Valia, et al.
Publicado: (2012)

Airway Epithelial Cultures of Children with Esophageal Atresia as a Model to Study Respiratory Tract Disorders
por: Dreyer, Henriette H. M., et al.
Publicado: (2023)

ADAM17 and EGFR regulate IL‐6 receptor and amphiregulin mRNA expression and release in cigarette smoke‐exposed primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD)
por: Stolarczyk, Marta, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_qp6nvsfqs4nh90cf5makblh4tp