Cargando…

New Pyrazole-Clubbed Pyrimidine or Pyrazoline Hybrids as Anti-Methicillin-Resistant Staphylococcus aureus Agents: Design, Synthesis, In Vitro and In Vivo Evaluation, and Molecular Modeling Simulation

[Image: see text] Two hybrid series of pyrazole-clubbed pyrimidines 5a–c and pyrazole-clubbed pyrazoline compounds 6a,b and 7 were designed as attractive scaffolds to be investigated in vitro and in vivo for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Pseudo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mansour, Basem, El-Sherbeny, Magda A., Al-Omary, Fatmah A. M., Saber, Sameh, Ramadan, Heba A., El-Baz, Ahmed M., Mourad, Ahmed A. E., Abdel-Aziz, Naglaa I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666275/ https://www.ncbi.nlm.nih.gov/pubmed/38027391 http://dx.doi.org/10.1021/acsomega.3c06936

Ejemplares similares

Pyrazoles and Pyrazolines as Anti-Inflammatory Agents
por: Mantzanidou, Martha, et al.
Publicado: (2021)

Molecular characterization of enterotoxin genes in methicillin-resistant S. aureus isolated from food poisoning outbreaks in Egypt
por: Ramadan, Heba A., et al.
Publicado: (2023)

Synthesis, Antibacterial and Antifungal Activity of Some New Pyrazoline and Pyrazole Derivatives
por: Hassan, Seham Y.
Publicado: (2013)

Antimicrobial Evaluation of New Pyrazoles, Indazoles and Pyrazolines Prepared in Continuous Flow Mode
por: Burke, Adam, et al.
Publicado: (2023)

A Unified Continuous Flow Assembly Line Synthesis of Highly Substituted Pyrazoles and Pyrazolines
por: Britton, Joshua, et al.
Publicado: (2017)

Design, synthesis, X-ray crystal structures, anticancer, DNA binding, and molecular modelling studies of pyrazole–pyrazoline hybrid derivatives
por: Rana, Manish, et al.
Publicado: (2023)

Synthesis and Molecular Docking Study of New Thiazole Derivatives as Potential Tubulin Polymerization Inhibitors
por: El-Abd, Azhar O., et al.
Publicado: (2022)

5-Propyl-6-(p-tolylsulfanyl)pyrimidine-2,4(1H,3H)-dione
por: Al-Omary, Fatmah A. M., et al.
Publicado: (2014)

Synthesis of New Pyrazole and Pyrimidine Steroidal Derivatives
por: Rivera, Daniel G., et al.
Publicado: (2003)

Synthetic approaches, structure activity relationship and biological applications for pharmacologically attractive pyrazole/pyrazoline–thiazolidine-based hybrids
por: Havrylyuk, Dmytro, et al.
Publicado: (2016)

Advantages of Cubosomal Formulation for Gatifloxacin Delivery in the Treatment of Bacterial Keratitis: In Vitro and In Vivo Approach Using Clinical Isolate of Methicillin-Resistant Staphylococcus aureus
por: Nasr, Mohamed, et al.
Publicado: (2022)

Visible-light-induced [3+2] cycloadditions of donor/donor diazo intermediates with alkenes to achieve (spiro)-pyrazolines and pyrazoles
por: Zhang, Yu, et al.
Publicado: (2023)

4-(4-Bromophenylhydrazono)-1-(5-bromopyrimidin-2-yl)-3-methyl-2-pyrazolin-5-one
por: Subramanyam, M., et al.
Publicado: (2008)

Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential antitumor candidates targeting both EGFR and VEGFR-2; design, synthesis, biological evaluations, and in silico studies
por: Al-Muntaser, Samia M., et al.
Publicado: (2023)

Kallolide A acetate pyrazoline
por: Rodríguez-Escudero, Idaliz, et al.
Publicado: (2011)

Synthesis and Biological Activity of Some New Pyrazoline and Pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives: Reaction of Nitrilimines with Some Dipolarophiles
por: Abunada, Nada M., et al.
Publicado: (2008)

Design, synthesis, molecular modelling and biological evaluation of novel 3-(2-naphthyl)-1-phenyl-1H-pyrazole derivatives as potent antioxidants and 15-Lipoxygenase inhibitors
por: Ali, Sahar A., et al.
Publicado: (2020)

A Novel Combination Therapy Using Rosuvastatin and Lactobacillus Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome Composition
por: Saber, Sameh, et al.
Publicado: (2021)

Synthesis of enones, pyrazolines and pyrrolines with gem-difluoroalkyl side chains
por: El Dine, Assaad Nasr, et al.
Publicado: (2013)

Synthesis and Bioactivity Assessment of Novel Spiro Pyrazole-Oxindole Congeners Exhibiting Potent and Selective in vitro Anticancer Effects
por: Abo-Salem, Heba M., et al.
Publicado: (2020)

Novel Potent and Selective DPP-4 Inhibitors: Design, Synthesis and Molecular Docking Study of Dihydropyrimidine Phthalimide Hybrids
por: Mourad, Ahmed A. E., et al.
Publicado: (2021)

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens
por: Al-Warhi, Tarfah, et al.
Publicado: (2022)

Soil-Associated Bacillus Species: A Reservoir of Bioactive Compounds with Potential Therapeutic Activity against Human Pathogens
por: Yahya, Galal, et al.
Publicado: (2021)

Pyrazoline Containing Compounds as Therapeutic Targets for Neurodegenerative Disorders
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2022)

Unusual rearrangement of imidazo[1,5-a]imidazoles and imidazo[1,2-b]pyrazoles into imidazo[1,5-a]pyrimidines and pyrazolo[1,5-a]pyrimidines
por: Gambouz, Khadija, et al.
Publicado: (2019)

Novel 2-Pyrazoline Derivatives as Potential Antibacterial and Antifungal Agents
por: Kini, Suvarna, et al.
Publicado: (2008)

Synthesis, quantitative structure–property relationship study of novel fluorescence active 2-pyrazolines and application
por: Girgis, Adel S., et al.
Publicado: (2018)

Novel piperazine–chalcone hybrids and related pyrazoline analogues targeting VEGFR-2 kinase; design, synthesis, molecular docking studies, and anticancer evaluation
por: Ahmed, Marwa F., et al.
Publicado: (2020)

Synthesis and Crystal Structures of N-Substituted Pyrazolines
por: Loh, Wan-Sin, et al.
Publicado: (2013)

Pyrazoline derivatives as promising novel antischistosomal agents
por: Morais, Cristiane S., et al.
Publicado: (2021)

Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities
por: Ramadan, Mohamed, et al.
Publicado: (2021)

Waste-Derived NPK Nanofertilizer Enhances Growth and Productivity of Capsicum annuum L.
por: Abdel-Aziz, Heba M. M., et al.
Publicado: (2021)

Rational Design and Synthesis of Diverse Pyrimidine Molecules Bearing Sulfonamide Moiety as Novel ERK Inhibitors
por: Halawa, Ahmed H., et al.
Publicado: (2019)

Multifunctional Aspects of the Synthesized Pyrazoline Derivatives for AP1 5L X60 Steel Protection Against MIC and Acidization: Electrochemical, In Silico, and SRB Insights
por: Abbas, Mohamed A., et al.
Publicado: (2021)

Methicillin- and Vancomycin-Resistant Staphylococcus aureus From Humans and Ready-To-Eat Meat: Characterization of Antimicrobial Resistance and Biofilm Formation Ability
por: Saber, Taisir, et al.
Publicado: (2022)

Androgen Receptor Antagonists and Anti-Prostate Cancer Activities of Some Newly Synthesized Substituted Fused Pyrazolo-, Triazolo- and Thiazolo-Pyrimidine Derivatives
por: Bahashwan, Saleh A., et al.
Publicado: (2014)

Synthesis and Structure–Activity Relationships of 4-Morpholino-7,8-Dihydro-5H-Thiopyrano[4,3-d]pyrimidine Derivatives Bearing Pyrazoline Scaffold
por: Wang, Qinqin, et al.
Publicado: (2017)

Antitumor, Analgesic, and Anti-inflammatory Activities of Synthesized Pyrazolines
por: Jainey, PJ, et al.
Publicado: (2012)

N-(12-Amino-9,10-dihydro-9,10-ethanoanthracen-11-yl)-4-methylbenzenesulfonamide
por: Mague, Joel T., et al.
Publicado: (2014)

4-[(1,3-Dioxoisoindolin-2-yl)methyl]benzenesulfonamide
por: Mague, Joel T., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_8h11hdfurqsq9q0086qfhsv2d6