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Disrupted cardiac fibroblast BCAA catabolism contributes to diabetic cardiomyopathy via a periostin/NAP1L2/SIRT3 axis

BACKGROUND: Periostin is an extracellular matrix protein that plays a critical role in cell fate determination and tissue remodeling, but the underlying role and mechanism of periostin in diabetic cardiomyopathy (DCM) are far from clear. Thus, we aimed to clarify the mechanistic participation of per...

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Detalles Bibliográficos
Autores principales: Lu, Qing-Bo, Fu, Xiao, Liu, Yao, Wang, Zi-Chao, Liu, Shi-Yi, Li, Yu-Chao, Sun, Hai-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666354/
https://www.ncbi.nlm.nih.gov/pubmed/37993768
http://dx.doi.org/10.1186/s11658-023-00510-4