Cargando…

Neutrophil-specific ORAI1 Calcium Channel Inhibition Reduces Pancreatitis-associated Acute Lung Injury

Acute pancreatitis is initiated within pancreatic exocrine cells and sustained by dysregulated systemic inflammatory responses mediated by neutrophils. Store-operated Ca(2+) entry (SOCE) through ORAI1 channels in pancreatic acinar cells triggers acute pancreatitis, and ORAI1 inhibitors ameliorate ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Niu, Mengya, Zhang, Xiuli, Wu, Zengkai, Li, Bin, Bao, Jingpiao, Dai, Juanjuan, Yang, Zihan, Zeng, Yue, Li, Liang, Pandol, Stephen, Sutton, Robert, Wen, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666672/ https://www.ncbi.nlm.nih.gov/pubmed/38020066 http://dx.doi.org/10.1093/function/zqad061

Ejemplares similares

Inhibition of Matrix Metalloproteinase with BB-94 Protects against Caerulein-Induced Pancreatitis via Modulating Neutrophil and Macrophage Activation
por: Wu, Zengkai, et al.
Publicado: (2020)

Orai1 calcium channels in the vasculature
por: Beech, David J
Publicado: (2012)

Orai1 calcium channel inhibition prevents progression of chronic pancreatitis
por: Szabó, Viktória, et al.
Publicado: (2023)

Systematic Characterization of the Clinical Relevance of KPNA4 in Pancreatic Ductal Adenocarcinoma
por: Bao, Jingpiao, et al.
Publicado: (2022)

Molecular understanding of calcium permeation through the open Orai channel
por: Liu, Xiaofen, et al.
Publicado: (2019)

Corrigendum: Systematic characterization of the clinical relevance of KPNA4 in pancreatic ductal adenocarcinoma
por: Bao, Jingpiao, et al.
Publicado: (2023)

Structures reveal opening of the store-operated calcium channel Orai
por: Hou, Xiaowei, et al.
Publicado: (2018)

ORAI Calcium Channels: Regulation, Function, Pharmacology, and Therapeutic Targets
por: Rubaiy, Hussein N.
Publicado: (2023)

Orai channel C-terminal peptides are key modulators of STlM-Orai coupling and calcium signal generation
por: Baraniak, James H., et al.
Publicado: (2021)

Dopamine D2 Receptor Signaling Attenuates Acinar Cell Necroptosis in Acute Pancreatitis through the Cathepsin B/TFAM/ROS Pathway
por: Wu, Zengkai, et al.
Publicado: (2022)

Cryo-EM structure of the calcium release-activated calcium channel Orai in an open conformation
por: Hou, Xiaowei, et al.
Publicado: (2020)

Antibody-Mediated Targeting of the Orai1 Calcium Channel Inhibits T Cell Function
por: Cox, Jennifer H., et al.
Publicado: (2013)

Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
por: Yu, Changhui, et al.
Publicado: (2022)

α-SNAP regulates dynamic, on-site assembly and calcium selectivity of Orai1 channels
por: Li, Peiyao, et al.
Publicado: (2016)

Orai3 Regulates Pancreatic Cancer Metastasis by Encoding a Functional Store Operated Calcium Entry Channel
por: Arora, Samriddhi, et al.
Publicado: (2021)

Calcium, Orai1 and Epidermal Proliferation
por: Bikle, DD, et al.
Publicado: (2014)

InsP(3) receptors and Orai channels in pancreatic acinar cells: co-localization and its consequences
por: Lur, Gyorgy, et al.
Publicado: (2011)

The calcium channel Orai1 is required for osteoblast development: Studies in a chimeric mouse with variable in vivo Runx-cre deletion of Orai-1
por: Robinson, Lisa J., et al.
Publicado: (2023)

Toward a Model for Activation of Orai Channel
por: Dong, Hao, et al.
Publicado: (2019)

Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models
por: Wen, Li, et al.
Publicado: (2015)

ORAI channels are critical for receptor-mediated endocytosis of albumin
por: Zeng, Bo, et al.
Publicado: (2017)

Orai3 Calcium Channel Regulates Breast Cancer Cell Migration through Calcium-Dependent and -Independent Mechanisms
por: Chamlali, Mohamed, et al.
Publicado: (2021)

High affinity associations with α-SNAP enable calcium entry via Orai1 channels
por: Ramanagoudr-Bhojappa, Ramanagouda, et al.
Publicado: (2021)

Astrocyte reactivity and inflammation-induced depression-like behaviors are regulated by Orai1 calcium channels
por: Novakovic, Michaela M., et al.
Publicado: (2023)

Quantal calcium release and calcium entry in the pancreatic acinar cell.
por: Pandol, S. J., et al.
Publicado: (1992)

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
por: Emrich, Scott M, et al.
Publicado: (2023)

Structural Insights into Ca(2+) Permeation through Orai Channels
por: Li, Yang, et al.
Publicado: (2021)

Endoplasmic reticulum stress promoted acinar cell necroptosis in acute pancreatitis through cathepsinB-mediated AP-1 activation
por: Han, Xiao, et al.
Publicado: (2022)

ORAI1 Crac Channel in Immune Cell is a Therapeutic Target for Pancreatitis-Associated Acute Lung Injury
por: Peng, Shuang, et al.
Publicado: (2023)

Inhibitory effects of α-Mangostin on T cell cytokine secretion via ORAI1 calcium channel and K(+) channels inhibition
por: Kim, Hyun Jong, et al.
Publicado: (2021)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

The remote allosteric control of Orai channel gating
por: Zhou, Yandong, et al.
Publicado: (2019)

Calcium Channel Protein ORAI1 Mediates TGF-β Induced Epithelial-to-Mesenchymal Transition in Colorectal Cancer Cells
por: Kang, Qingjie, et al.
Publicado: (2021)

The plasma membrane channel ORAI1 mediates detrimental calcium influx caused by endogenous oxidative stress
por: Henke, N, et al.
Publicado: (2013)

The Love Story between Orai Calcium Entry Channels and Adenylyl Cyclases Gets even more Complicated
por: Hofer, Aldebaran M
Publicado: (2021)

Orai1 and Orai3 in Combination with Stim1 Mediate the Majority of Store-operated Calcium Entry in Astrocytes
por: Kwon, Jea, et al.
Publicado: (2017)

SOAR and the polybasic STIM1 domains gate and regulate the Orai channels
por: Yuan, Joseph P., et al.
Publicado: (2009)

Thiol dependent intramolecular locking of Orai1 channels
por: Alansary, Dalia, et al.
Publicado: (2016)

The exquisitely cooperative nature of Orai1 channel activation
por: Yeung, Priscilla See-Wai, et al.
Publicado: (2018)

Orai channels: key players in Ca(2+) homeostasis
por: Sallinger, Matthias, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_1s0u5pshg4ajuoj884s2n65i76