Unveiling the noncanonical activation mechanism of CDKs: insights from recent structural studies

The Cyclin-dependent kinases (CDKs) play crucial roles in a range of essential cellular processes. While the classical two-step activation mechanism is generally applicable to cell cycle-related CDKs, both CDK7 and CDK8, involved in transcriptional regulation, adopt distinct mechanisms for kinase ac...

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Detalles Bibliográficos
Autores principales: Li, Tao, Tang, Hui-Chi, Tsai, Kuang-Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666765/
https://www.ncbi.nlm.nih.gov/pubmed/38028546
http://dx.doi.org/10.3389/fmolb.2023.1290631

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666765/
https://www.ncbi.nlm.nih.gov/pubmed/38028546
http://dx.doi.org/10.3389/fmolb.2023.1290631

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