An Acute Promyelocytic Leukemia Resistant to All-Trans Retinoic Acid: A Case Report of the ZBTB16::RARa Variant and Review of the Literature

INTRODUCTION: Acute promyelocytic leukemia (APL) is characterized by the PML::RARa gene fusion and treatment consists of all-trans retinoic acid (ATRA). Rarely, genetic APL variants have been described which are insensitive to ATRA treatment and are therefore associated with a worse prognosis. Rapid...

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Detalles Bibliográficos
Autores principales: Castelijn, Daan A.R., Sijm, Gerrit, Venniker-Punt, Bianca, Poddighe, Pino J., Wondergem, Marielle J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10666957/
https://www.ncbi.nlm.nih.gov/pubmed/38028572
http://dx.doi.org/10.1159/000534862