Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators

The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA(A) receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target comp...

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Autores principales: Vega Alanis, Blanca Angelica, Wimmer, Laurin, Ernst, Margot, Schnürch, Michael, Mihovilovic, Marko D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667146/
https://www.ncbi.nlm.nih.gov/pubmed/38020488
http://dx.doi.org/10.1007/s00706-023-03063-6
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author Vega Alanis, Blanca Angelica
Wimmer, Laurin
Ernst, Margot
Schnürch, Michael
Mihovilovic, Marko D.
author_facet Vega Alanis, Blanca Angelica
Wimmer, Laurin
Ernst, Margot
Schnürch, Michael
Mihovilovic, Marko D.
author_sort Vega Alanis, Blanca Angelica
collection PubMed
description The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA(A) receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00706-023-03063-6.
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spelling pubmed-106671462023-04-13 Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators Vega Alanis, Blanca Angelica Wimmer, Laurin Ernst, Margot Schnürch, Michael Mihovilovic, Marko D. Monatsh Chem Original Paper The synthesis of novel pyrazolothienopyridinone derivatives as potential GABA(A) receptor modulators was performed and is herein described. A crucial step of the synthesis involving handling unstable aminothiophenes was managed via two different synthetic strategies delivering a set of 8 target compounds. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00706-023-03063-6. Springer Vienna 2023-04-13 2023 /pmc/articles/PMC10667146/ /pubmed/38020488 http://dx.doi.org/10.1007/s00706-023-03063-6 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Vega Alanis, Blanca Angelica
Wimmer, Laurin
Ernst, Margot
Schnürch, Michael
Mihovilovic, Marko D.
Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
title Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
title_full Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
title_fullStr Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
title_full_unstemmed Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
title_short Novel pyrazolothienopyridinones as potential GABA(A) receptor modulators
title_sort novel pyrazolothienopyridinones as potential gaba(a) receptor modulators
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667146/
https://www.ncbi.nlm.nih.gov/pubmed/38020488
http://dx.doi.org/10.1007/s00706-023-03063-6
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