Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy

Pancreatic cancer cells with mutant KRAS require strong basal autophagy for viability and growth. Here, we observed that some processes that allow the maintenance of basal autophagy in pancreatic cancer cells are controlled by protein methylation. Thus, by maintaining the methylation status of prote...

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Detalles Bibliográficos
Autores principales: Montenegro, María F., Martí-Díaz, Román, Navarro, Ana, Tolivia, Jorge, Sánchez-del-Campo, Luis, Cabezas-Herrera, Juan, Rodríguez-López, José Neptuno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667277/
https://www.ncbi.nlm.nih.gov/pubmed/37996408
http://dx.doi.org/10.1038/s41419-023-06288-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667277/
https://www.ncbi.nlm.nih.gov/pubmed/37996408
http://dx.doi.org/10.1038/s41419-023-06288-9

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