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Targeting protein methylation in pancreatic cancer cells results in KRAS signaling imbalance and inhibition of autophagy
Pancreatic cancer cells with mutant KRAS require strong basal autophagy for viability and growth. Here, we observed that some processes that allow the maintenance of basal autophagy in pancreatic cancer cells are controlled by protein methylation. Thus, by maintaining the methylation status of prote...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667277/ https://www.ncbi.nlm.nih.gov/pubmed/37996408 http://dx.doi.org/10.1038/s41419-023-06288-9 |