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Dissecting aneuploidy phenotypes by constructing Sc2.0 chromosome VII and SCRaMbLEing synthetic disomic yeast

Aneuploidy compromises genomic stability, often leading to embryo inviability, and is frequently associated with tumorigenesis and aging. Different aneuploid chromosome stoichiometries lead to distinct transcriptomic and phenotypic changes, making it helpful to study aneuploidy in tightly controlled...

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Detalles Bibliográficos
Autores principales: Shen, Yue, Gao, Feng, Wang, Yun, Wang, Yuerong, Zheng, Ju, Gong, Jianhui, Zhang, Jintao, Luo, Zhouqing, Schindler, Daniel, Deng, Yang, Ding, Weichao, Lin, Tao, Swidah, Reem, Zhao, Hongcui, Jiang, Shuangying, Zeng, Cheng, Chen, Shihong, Chen, Tai, Wang, Yong, Luo, Yisha, Mitchell, Leslie, Bader, Joel S., Zhang, Guojie, Shen, Xia, Wang, Jian, Fu, Xian, Dai, Junbiao, Boeke, Jef D., Yang, Huanming, Xu, Xun, Cai, Yizhi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667312/
https://www.ncbi.nlm.nih.gov/pubmed/38020968
http://dx.doi.org/10.1016/j.xgen.2023.100364