Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death

Ocular hypertension during glaucoma can lead to hypoxia, activation of the HIF transcription factors, and a metabolic shift toward glycolysis. This study aims to test whether chronic HIF activation and the attendant metabolic reprogramming can initiate glaucoma-associated pathology independently of...

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Detalles Bibliográficos
Autores principales: Nsiah, Nana Yaa, Morgan, Autumn B., Donkor, Nina, Inman, Denise M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667534/
https://www.ncbi.nlm.nih.gov/pubmed/37996657
http://dx.doi.org/10.1038/s41598-023-47942-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667534/
https://www.ncbi.nlm.nih.gov/pubmed/37996657
http://dx.doi.org/10.1038/s41598-023-47942-8

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