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Long-term HIF-1α stabilization reduces respiration, promotes mitophagy, and results in retinal cell death
Ocular hypertension during glaucoma can lead to hypoxia, activation of the HIF transcription factors, and a metabolic shift toward glycolysis. This study aims to test whether chronic HIF activation and the attendant metabolic reprogramming can initiate glaucoma-associated pathology independently of...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667534/ https://www.ncbi.nlm.nih.gov/pubmed/37996657 http://dx.doi.org/10.1038/s41598-023-47942-8 |