Targeting USP8 Inhibits O‐GlcNAcylation of SLC7A11 to Promote Ferroptosis of Hepatocellular Carcinoma via Stabilization of OGT

Hepatocellular carcinoma (HCC) is a lethal and aggressive human malignancy. The present study examins the anti‐tumor effects of deubiquitylating enzymes (DUB) inhibitors in HCC. It is found that the inhibitor of ubiquitin specific peptidase 8 (USP8) and DUB‐IN‐3 shows the most effective anti‐cancer...

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Detalles Bibliográficos
Autores principales: Tang, Jianing, Long, Guo, Hu, Kuan, Xiao, Desheng, Liu, Shuang, Xiao, Liang, Zhou, Ledu, Tao, Yongguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667802/
https://www.ncbi.nlm.nih.gov/pubmed/37867237
http://dx.doi.org/10.1002/advs.202302953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667802/
https://www.ncbi.nlm.nih.gov/pubmed/37867237
http://dx.doi.org/10.1002/advs.202302953

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