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A Lightweight Framework For Chromatin Loop Detection at the Single‐Cell Level

Single‐cell Hi‐C (scHi‐C) has made it possible to analyze chromatin organization at the single‐cell level. However, scHi‐C experiments generate inherently sparse data, which poses a challenge for loop calling methods. The existing approach performs significance tests across the imputed dense contact...

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Detalles Bibliográficos
Autores principales: Wang, Fuzhou, Alinejad‐Rokny, Hamid, Lin, Jiecong, Gao, Tingxiao, Chen, Xingjian, Zheng, Zetian, Meng, Lingkuan, Li, Xiangtao, Wong, Ka‐Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667817/
https://www.ncbi.nlm.nih.gov/pubmed/37816141
http://dx.doi.org/10.1002/advs.202303502