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Methionine Restriction Impairs Degradation of a Protein that Aberrantly Engages the Endoplasmic Reticulum Translocon

Proteins that persistently engage endoplasmic reticulum (ER) translocons are degraded by multiple translocon quality control (TQC) mechanisms. In Saccharomyces cerevisiae , the model translocon-associated protein Deg1 -Sec62 is subject to ER-associated degradation (ERAD) by the Hrd1 ubiquitin ligase...

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Detalles Bibliográficos
Autores principales: Runnebohm, Avery M., Indovina, Christopher J., Turk, Samantha M., Bailey, Connor G., Orchard, Cade J., Wade, Lauren, Overton, Danielle L., Snow, Brian J., Rubenstein, Eric M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Caltech Library 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10667923/
https://www.ncbi.nlm.nih.gov/pubmed/38021175
http://dx.doi.org/10.17912/micropub.biology.001021