Cell uptake and intracellular trafficking of bioreducible poly(amidoamine) nanoparticles for efficient mRNA translation in chondrocytes

Disulfide-containing poly(amidoamine) (PAA) is a cationic and bioreducible polymer, with potential use as a nanocarrier for mRNA delivery in the treatment of several diseases including osteoarthritis (OA). Successful transfection of joint cells with PAA-based nanoparticles (NPs) was shown previously...

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Detalles Bibliográficos
Autores principales: Pontes, Adriano P., van der Wal, Steffen, Ranamalla, Saketh R., Roelofs, Karin, Tomuta, Ioan, Creemers, Laura B., Rip, Jaap
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668025/
https://www.ncbi.nlm.nih.gov/pubmed/38026902
http://dx.doi.org/10.3389/fbioe.2023.1290871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668025/
https://www.ncbi.nlm.nih.gov/pubmed/38026902
http://dx.doi.org/10.3389/fbioe.2023.1290871

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