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A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit

Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on healthy mitochondria are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback loop of Parkin recruitment, which in turn promotes mitochon...

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Detalles Bibliográficos
Autores principales: Waters, Christopher S., Angenent, Sigurd B., Altschuler, Steven J., Wu, Lani F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668033/
https://www.ncbi.nlm.nih.gov/pubmed/37851575
http://dx.doi.org/10.1016/j.celrep.2023.113260