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A PINK1 input threshold arises from positive feedback in the PINK1/Parkin mitophagy decision circuit
Mechanisms that prevent accidental activation of the PINK1/Parkin mitophagy circuit on healthy mitochondria are poorly understood. On the surface of damaged mitochondria, PINK1 accumulates and acts as the input signal to a positive feedback loop of Parkin recruitment, which in turn promotes mitochon...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668033/ https://www.ncbi.nlm.nih.gov/pubmed/37851575 http://dx.doi.org/10.1016/j.celrep.2023.113260 |