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Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report
BACKGROUND: The aim of this report is to highlight the importance of considering nephrotic syndrome as a potential underlying cause of bilateral central serous retinal detachment in a patient with systemic lupus erythematosus and to underscore the significance of a comprehensive systemic workup in t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668382/ https://www.ncbi.nlm.nih.gov/pubmed/37996887 http://dx.doi.org/10.1186/s13256-023-04236-x |
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author | Sadeghi, Reza Pashapouryeganeh, Amirreza Karimi, Morteza Khalili Pour, Elias Mirghorbani, Masoud Riazi-Esfahani, Hamid |
author_facet | Sadeghi, Reza Pashapouryeganeh, Amirreza Karimi, Morteza Khalili Pour, Elias Mirghorbani, Masoud Riazi-Esfahani, Hamid |
author_sort | Sadeghi, Reza |
collection | PubMed |
description | BACKGROUND: The aim of this report is to highlight the importance of considering nephrotic syndrome as a potential underlying cause of bilateral central serous retinal detachment in a patient with systemic lupus erythematosus and to underscore the significance of a comprehensive systemic workup in these patients. CASE PRESENTATION: A 19-year-old Iranian female patient with history of systemic lupus erythematosus presented with progressive vision loss and bilateral macular elevation. Ophthalmic examination revealed periorbital edema, chemosis, and subretinal fluid at the macula of both eyes. Optical coherence tomography confirmed the existence of subretinal fluid and serous detachment located at the macula of both eyes. On fluorescein angiography, there were no signs of subretinal leakage such as smoke stack sign or expansile dot in late phases. Laboratory tests detected hypoalbuminemia and significant proteinuria, leading to the diagnosis of nephrotic syndrome. Treatment with prednisolone and albumin infusion resulted in improved visual acuity and resolution of subretinal fluid. CONCLUSION: Nephrotic syndrome can be a rare underlying cause of bilateral central serous retinal detachment, and its association with systemic lupus erythematosus should be considered. Hypoalbuminemia in nephrotic syndrome alters fluid dynamics in the retina, contributing to bilateral central serous retinal detachment. Early recognition and management of nephrotic syndrome are essential for vision recovery and preventing long-term complications. |
format | Online Article Text |
id | pubmed-10668382 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-106683822023-11-24 Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report Sadeghi, Reza Pashapouryeganeh, Amirreza Karimi, Morteza Khalili Pour, Elias Mirghorbani, Masoud Riazi-Esfahani, Hamid J Med Case Rep Case Report BACKGROUND: The aim of this report is to highlight the importance of considering nephrotic syndrome as a potential underlying cause of bilateral central serous retinal detachment in a patient with systemic lupus erythematosus and to underscore the significance of a comprehensive systemic workup in these patients. CASE PRESENTATION: A 19-year-old Iranian female patient with history of systemic lupus erythematosus presented with progressive vision loss and bilateral macular elevation. Ophthalmic examination revealed periorbital edema, chemosis, and subretinal fluid at the macula of both eyes. Optical coherence tomography confirmed the existence of subretinal fluid and serous detachment located at the macula of both eyes. On fluorescein angiography, there were no signs of subretinal leakage such as smoke stack sign or expansile dot in late phases. Laboratory tests detected hypoalbuminemia and significant proteinuria, leading to the diagnosis of nephrotic syndrome. Treatment with prednisolone and albumin infusion resulted in improved visual acuity and resolution of subretinal fluid. CONCLUSION: Nephrotic syndrome can be a rare underlying cause of bilateral central serous retinal detachment, and its association with systemic lupus erythematosus should be considered. Hypoalbuminemia in nephrotic syndrome alters fluid dynamics in the retina, contributing to bilateral central serous retinal detachment. Early recognition and management of nephrotic syndrome are essential for vision recovery and preventing long-term complications. BioMed Central 2023-11-24 /pmc/articles/PMC10668382/ /pubmed/37996887 http://dx.doi.org/10.1186/s13256-023-04236-x Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Case Report Sadeghi, Reza Pashapouryeganeh, Amirreza Karimi, Morteza Khalili Pour, Elias Mirghorbani, Masoud Riazi-Esfahani, Hamid Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
title | Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
title_full | Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
title_fullStr | Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
title_full_unstemmed | Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
title_short | Bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
title_sort | bilateral central serous retinal detachment in a patient with nephrotic syndrome: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668382/ https://www.ncbi.nlm.nih.gov/pubmed/37996887 http://dx.doi.org/10.1186/s13256-023-04236-x |
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