Activation of Kras(G12D) in Subset of Alveolar Type II Cells Enhances Cellular Plasticity in Lung Adenocarcinoma

We have previously identified alveolar type II cell as the cell-of-origin of Kras(G12D)-induced lung adenocarcinoma using cell lineage–specific inducible Cre mouse models. Using gain-of-function and loss-of-function genetic models, we discovered that active Notch signaling and low Sox2 levels dictat...

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Detalles Bibliográficos
Autores principales: Chaudhary, Priyanka, Xu, Xia, Wang, Guangfang, Hoj, Jacob P., Rampersad, Rishi R., Asselin-Labat, Marie-Liesse, Ting, Stephanie, Kim, William, Tamayo, Pablo, Pendergast, Ann Marie, Onaitis, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668634/
https://www.ncbi.nlm.nih.gov/pubmed/37882674
http://dx.doi.org/10.1158/2767-9764.CRC-22-0408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668634/
https://www.ncbi.nlm.nih.gov/pubmed/37882674
http://dx.doi.org/10.1158/2767-9764.CRC-22-0408

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