Unwinding the SARS-CoV-2 Ribosomal Frameshifting Pseudoknot with LNA and G-Clamp-Modified Phosphorothioate Oligonucleotides Inhibits Viral Replication

Ribosomal frameshifting (RFS) at the slippery site of SARS-CoV-2 RNA is essential for the biosynthesis of the viral replication machinery. It requires the formation of a pseudoknot (PK) structure near the slippery site and can be inhibited by PK-disrupting oligonucleotide-based antivirals. We obtain...

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Detalles Bibliográficos
Autores principales: Knizhnik, Ekaterina, Chumakov, Stepan, Svetlova, Julia, Pavlova, Iulia, Khodarovich, Yuri, Brylev, Vladimir, Severov, Vjacheslav, Alieva, Rugiya, Kozlovskaya, Liubov, Andreev, Dmitry, Aralov, Andrey, Varizhuk, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668963/
https://www.ncbi.nlm.nih.gov/pubmed/38002341
http://dx.doi.org/10.3390/biom13111660

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668963/
https://www.ncbi.nlm.nih.gov/pubmed/38002341
http://dx.doi.org/10.3390/biom13111660

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