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Unwinding the SARS-CoV-2 Ribosomal Frameshifting Pseudoknot with LNA and G-Clamp-Modified Phosphorothioate Oligonucleotides Inhibits Viral Replication
Ribosomal frameshifting (RFS) at the slippery site of SARS-CoV-2 RNA is essential for the biosynthesis of the viral replication machinery. It requires the formation of a pseudoknot (PK) structure near the slippery site and can be inhibited by PK-disrupting oligonucleotide-based antivirals. We obtain...
Autores principales: | Knizhnik, Ekaterina, Chumakov, Stepan, Svetlova, Julia, Pavlova, Iulia, Khodarovich, Yuri, Brylev, Vladimir, Severov, Vjacheslav, Alieva, Rugiya, Kozlovskaya, Liubov, Andreev, Dmitry, Aralov, Andrey, Varizhuk, Anna |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10668963/ https://www.ncbi.nlm.nih.gov/pubmed/38002341 http://dx.doi.org/10.3390/biom13111660 |
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