Intravitreal Injection of ZYAN1 Restored Autophagy and Alleviated Oxidative Stress in Degenerating Retina via the HIF-1α/BNIP3 Pathway

Mitochondrial autophagy plays a contributary role in the pathogenesis of retina degeneration (RD). ZYAN1 is a novel proline hydroxylase domain (PHD) inhibitor that can enhance the expression of hypoxia-inducible factor 1-alpha (HIF-1α). This study investigated whether ZYAN1 could alleviate progressi...

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Detalles Bibliográficos
Autores principales: Hao, Xiao-Na, Zhao, Na, Huang, Jie-Min, Li, Si-Yu, Wei, Dong, Pu, Ning, Peng, Guang-Hua, Tao, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669006/
https://www.ncbi.nlm.nih.gov/pubmed/38001767
http://dx.doi.org/10.3390/antiox12111914

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669006/
https://www.ncbi.nlm.nih.gov/pubmed/38001767
http://dx.doi.org/10.3390/antiox12111914

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