Cargando…

Intravitreal Injection of ZYAN1 Restored Autophagy and Alleviated Oxidative Stress in Degenerating Retina via the HIF-1α/BNIP3 Pathway

Mitochondrial autophagy plays a contributary role in the pathogenesis of retina degeneration (RD). ZYAN1 is a novel proline hydroxylase domain (PHD) inhibitor that can enhance the expression of hypoxia-inducible factor 1-alpha (HIF-1α). This study investigated whether ZYAN1 could alleviate progressi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hao, Xiao-Na, Zhao, Na, Huang, Jie-Min, Li, Si-Yu, Wei, Dong, Pu, Ning, Peng, Guang-Hua, Tao, Ye
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669006/ https://www.ncbi.nlm.nih.gov/pubmed/38001767 http://dx.doi.org/10.3390/antiox12111914

Ejemplares similares

Sevoflurane postconditioning alleviates hypoxia-reoxygenation injury of cardiomyocytes by promoting mitochondrial autophagy through the HIF-1/BNIP3 signaling pathway
por: Yang, Long, et al.
Publicado: (2019)

Deferoxamine Treatment Combined With Sevoflurane Postconditioning Attenuates Myocardial Ischemia-Reperfusion Injury by Restoring HIF-1/BNIP3-Mediated Mitochondrial Autophagy in GK Rats
por: Yang, Long, et al.
Publicado: (2020)

HIF-1α/BNIP3-Mediated Autophagy Contributes to the Luteinization of Granulosa Cells During the Formation of Corpus Luteum
por: Tang, Zonghao, et al.
Publicado: (2021)

Gujiansan Ameliorates Avascular Necrosis of the Femoral Head by Regulating Autophagy via the HIF-1α/BNIP3 Pathway
por: Han, Jie, et al.
Publicado: (2021)

Contribution of HIF-1α/BNIP3-mediated autophagy to lipid accumulation during irinotecan-induced liver injury
por: Shi, Congjian, et al.
Publicado: (2023)

Intravitreal Injection of IGFBP-3 Restores Normal Insulin Signaling in Diabetic Rat Retina
por: Jiang, Youde, et al.
Publicado: (2014)

Hypoxia-induced autophagy contributes to the invasion of salivary adenoid cystic carcinoma through the HIF-1α/BNIP3 signaling pathway
por: WU, HAIWEI, et al.
Publicado: (2015)

Photochemical Restoration of Light Sensitivity in the Degenerated Canine Retina
por: Nikonov, Sergei, et al.
Publicado: (2022)

Insufficient radiofrequency ablation-induced autophagy contributes to the rapid progression of residual hepatocellular carcinoma through the HIF-1α/BNIP3 signaling pathway
por: Xu, Wen-Lei, et al.
Publicado: (2019)

Hydroxysafflor Yellow A Exerts Neuroprotective Effects via HIF-1α/BNIP3 Pathway to Activate Neuronal Autophagy after OGD/R
por: Wei, Ruheng, et al.
Publicado: (2022)

BNIP3 promotes HIF‐1α‐driven melanoma growth by curbing intracellular iron homeostasis
por: Vara‐Pérez, Mónica, et al.
Publicado: (2021)

Autophagy/ Apoptosis Induced by Geraniol through HIF-1α/BNIP3/Beclin-1 Signaling Pathway in A549 CoCl2 Treated Cells
por: Abo El-Ella, Dina M.
Publicado: (2022)

RNF185, a Novel Mitochondrial Ubiquitin E3 Ligase, Regulates Autophagy through Interaction with BNIP1
por: Tang, Fei, et al.
Publicado: (2011)

Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration
por: Xu, Wenchang, et al.
Publicado: (2023)

Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway
por: Peng, Yonghan, et al.
Publicado: (2019)

Phase I Clinical Study of ZYAN1, A Novel Prolyl-Hydroxylase (PHD) Inhibitor to Evaluate the Safety, Tolerability, and Pharmacokinetics Following Oral Administration in Healthy Volunteers
por: Kansagra, Kevinkumar A., et al.
Publicado: (2017)

Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells
por: Xie, Chenglong, et al.
Publicado: (2022)

Protective effects of Gypenoside XVII against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy
por: Xie, Weijie, et al.
Publicado: (2022)

Intravitreal NGF administration counteracts retina degeneration after permanent carotid artery occlusion in rat
por: Sivilia, Sandra, et al.
Publicado: (2009)

HIF-1α-BNIP3-mediated mitophagy in tubular cells protects against renal ischemia/reperfusion injury
por: Fu, Zong-Jie, et al.
Publicado: (2020)

Correction to: Testosterone induces renal tubular epithelial cell death through the HIF-1α/BNIP3 pathway
por: Peng, Yonghan, et al.
Publicado: (2021)

HIF-1α/BNIP3L induced cognitive deficits in a mouse model of sepsis-associated encephalopathy
por: Zhao, Lina, et al.
Publicado: (2022)

Role of the HIF-1α/BNIP3 Signaling Pathway in Recurrent Hepatocellular Carcinoma and the Mechanism of Traditional Chinese Medicine
por: Liu, Sizhe, et al.
Publicado: (2023)

Impact of Intravitreal Injection of Bevacizumab (Avastin) on Rabbit's Choroid and Retina
por: Karawya, Sherif, et al.
Publicado: (2008)

A protocol for the retina surgeon’s safe initial intravitreal injections
por: Frenkel, Ronald EP, et al.
Publicado: (2010)

Survey of intravitreal injection techniques among retina specialists in Israel
por: Segal, Ori, et al.
Publicado: (2016)

Survey of Intravitreal Injection Techniques Among Retina Specialists in Mexico
por: Henaine-Berra, Andree, et al.
Publicado: (2020)

Rescue of Retinal Degeneration in rd1 Mice by Intravitreally Injected Metformin
por: A, Luodan, et al.
Publicado: (2019)

Inhibiting NLRP3 inflammasome attenuates apoptosis in contrast-induced acute kidney injury through the upregulation of HIF1A and BNIP3-mediated mitophagy
por: Lin, Qisheng, et al.
Publicado: (2020)

The MAP Kinase Phosphatase MKP-1 Modulates Neurogenesis via Effects on BNIP3 and Autophagy
por: Li, Yinghui, et al.
Publicado: (2021)

Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration
por: Zou, Ming, et al.
Publicado: (2022)

EBV-LMP1 promotes radioresistance by inducing protective autophagy through BNIP3 in nasopharyngeal carcinoma
por: Xu, San, et al.
Publicado: (2021)

Inhibition of BMK1 pathway suppresses cancer stem cells through BNIP3 and BNIP3L
por: Song, Chengli, et al.
Publicado: (2015)

Involvement of autophagy in hypoxia-BNIP3 signaling to promote epidermal keratinocyte migration
por: Zhang, Junhui, et al.
Publicado: (2019)

Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy
por: Vianello, Caterina, et al.
Publicado: (2022)

Catalytic Nanoceria Are Preferentially Retained in the Rat Retina and Are Not Cytotoxic after Intravitreal Injection
por: Wong, Lily L., et al.
Publicado: (2013)

Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils
por: Pérez-Acuña, Dayana, et al.
Publicado: (2023)

Exogenous Ang-(1-7) inhibits autophagy via HIF-1α/THBS1/BECN1 axis to alleviate chronic intermittent hypoxia-enhanced airway remodelling of asthma
por: Zhou, Jian Ping, et al.
Publicado: (2023)

HIF-1α/Beclin1-Mediated Autophagy Is Involved in Neuroprotection Induced by Hypoxic Preconditioning
por: Lu, Na, et al.
Publicado: (2018)

HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
por: Li, Jialin, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_srpgsdofj0db2sb2nkv8rcb362