Novel Covalent Modifier-Induced Local Conformational Changes within the Intrinsically Disordered Region of the Androgen Receptor

SIMPLE SUMMARY: The androgen receptor (AR) is an important protein involved in sensing hormones. The over-activation of a class of AR can lead to cellular dysfunction and diseases such as prostate cancer. This malfunction is connected to abnormal protein clusters known as condensates. To address thi...

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Detalles Bibliográficos
Autores principales: Harnish, Michael T., Lopez, Daniel, Morrison, Corbin T., Narayanan, Ramesh, Fernandez, Elias J., Shen, Tongye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669190/
https://www.ncbi.nlm.nih.gov/pubmed/37998041
http://dx.doi.org/10.3390/biology12111442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669190/
https://www.ncbi.nlm.nih.gov/pubmed/37998041
http://dx.doi.org/10.3390/biology12111442

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