Cargando…

Astrocytic Nrf2 Mediates the Neuroprotective and Anti-Inflammatory Effects of Nootkatone in an MPTP-Induced Parkinson’s Disease Mouse Model

This study aims to investigate the neuroprotective effects of nootkatone (NKT), a sesquiterpenoid compound isolated from grapefruit, in an MPTP-induced Parkinson’s disease (PD) mouse model. NKT restored MPTP-induced motor impairment and dopaminergic neuronal loss and increased the expression of neur...

Descripción completa

Detalles Bibliográficos
Autores principales:	Park, Jung-Eun, Leem, Yea-Hyun, Park, Jin-Sun, Kim, Seong-Eun, Kim, Hee-Sun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669233/ https://www.ncbi.nlm.nih.gov/pubmed/38001852 http://dx.doi.org/10.3390/antiox12111999

Ejemplares similares

Neuroprotective Effect of β-Lapachone in MPTP-Induced Parkinson’s Disease Mouse Model: Involvement of Astroglial p-AMPK/Nrf2/HO-1 Signaling Pathways
por: Park, Jin-Sun, et al.
Publicado: (2019)

Necrosulfonamide exerts neuroprotective effect by inhibiting necroptosis, neuroinflammation, and α-synuclein oligomerization in a subacute MPTP mouse model of Parkinson’s disease
por: Leem, Yea-Hyun, et al.
Publicado: (2023)

Papaverine Exerts Neuroprotective Effect by Inhibiting NLRP3 Inflammasome Activation in an MPTP-Induced Microglial Priming Mouse Model Challenged with LPS
por: Leem, Yea-Hyun, et al.
Publicado: (2021)

RIPK1 Regulates Microglial Activation in Lipopolysaccharide-Induced Neuroinflammation and MPTP-Induced Parkinson’s Disease Mouse Models
por: Kim, Do-Yeon, et al.
Publicado: (2023)

Neurogenic effects of rotarod walking exercise in subventricular zone, subgranular zone, and substantia nigra in MPTP-induced Parkinson’s disease mice
por: Leem, Yea-Hyun, et al.
Publicado: (2022)

Anti-Inflammatory and Neuroprotective Mechanisms of GTS-21, an α7 Nicotinic Acetylcholine Receptor Agonist, in Neuroinflammation and Parkinson’s Disease Mouse Models
por: Park, Jung-Eun, et al.
Publicado: (2022)

The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson’s disease mouse models
por: Lee, Yu-Young, et al.
Publicado: (2019)

The Neuroprotective Effects of Cinnamic Aldehyde in an MPTP Mouse Model of Parkinson’s Disease
por: Bae, Woom-Yee, et al.
Publicado: (2018)

Anti-Inflammatory and Neuroprotective Effects of Morin in an MPTP-Induced Parkinson’s Disease Model
por: Hong, Dong Geun, et al.
Publicado: (2022)

Neuroprotective and Anti-Inflammatory Effects of Evernic Acid in an MPTP-Induced Parkinson’s Disease Model
por: Lee, Seulah, et al.
Publicado: (2021)

Acylated but not des‐acyl ghrelin is neuroprotective in an MPTP mouse model of Parkinson's disease
por: Bayliss, Jacqueline A., et al.
Publicado: (2016)

Catalpol Exerts a Neuroprotective Effect in the MPTP Mouse Model of Parkinson’s Disease
por: Wang, Li-Yuan, et al.
Publicado: (2019)

Nootkatone Inhibits Acute and Chronic Inflammatory Responses in Mice
por: Bezerra Rodrigues Dantas, Lindaiane, et al.
Publicado: (2020)

Gypenosides ameliorate memory deficits in MPTP-lesioned mouse model of Parkinson’s disease treated with L-DOPA
por: Zhao, Ting Ting, et al.
Publicado: (2017)

Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson’s Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways
por: Rehman, Inayat Ur, et al.
Publicado: (2022)

The effects of peripherally-subacute treatment with irisin on hippocampal dendritogenesis and astrocyte-secreted factors
por: Kim, Mun-Hee, et al.
Publicado: (2019)

Neuroprotective Effects of Bifidobacterium breve CCFM1067 in MPTP-Induced Mouse Models of Parkinson’s Disease
por: Li, Tiantian, et al.
Publicado: (2022)

Pretreatment of caffeine leads to partial neuroprotection in MPTP model of Parkinson's disease
por: Bagga, Puneet, et al.
Publicado: (2016)

Preparation and Neuroprotective Activity of Glucuronomannan Oligosaccharides in an MPTP-Induced Parkinson’s Model
por: Liu, Yingjuan, et al.
Publicado: (2020)

Neuroprotective Effect of Ceftriaxone on MPTP-Induced Parkinson's Disease Mouse Model by Regulating Inflammation and Intestinal Microbiota
por: Zhou, Xiaoting, et al.
Publicado: (2021)

Characterization of Nasco grape pomace-loaded nutriosomes and their neuroprotective effects in the MPTP mouse model of Parkinson’s disease
por: Parekh, Pathik, et al.
Publicado: (2022)

Proposed Motor Scoring System in a Porcine Model of Parkinson's Disease induced by Chronic Subcutaneous Injection of MPTP
por: Moon, Joon Ho, et al.
Publicado: (2014)

Novel Insect Antifeedant and Ixodicidal Nootkatone Derivatives
por: Galisteo Pretel, Alberto, et al.
Publicado: (2019)

PEP-1-HO-1 prevents MPTP-induced degeneration of dopaminergic neurons in a Parkinson’s disease mouse model
por: Youn, Jong Kyu, et al.
Publicado: (2014)

Co-Administration of Gagam-Sipjeondaebo-Tang and Ibuprofen Alleviates the Inflammatory Response in MPTP-Induced Parkinson’s Disease Mouse Model and RAW264.7 Macrophages
por: Won, Sodam, et al.
Publicado: (2021)

Inflammatory Response Modulation by Vitamin C in an MPTP Mouse Model of Parkinson’s Disease
por: De Nuccio, Francesco, et al.
Publicado: (2021)

Neuroprotective changes in degeneration-related gene expression in the substantia nigra following acupuncture in an MPTP mouse model of Parkinsonism: Microarray analysis
por: Yeo, Sujung, et al.
Publicado: (2015)

Neuroprotective and Neurorestorative Effects of Holothuria scabra Extract in the MPTP/MPP(+)-Induced Mouse and Cellular Models of Parkinson’s Disease
por: Noonong, Kunwadee, et al.
Publicado: (2020)

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease
por: Yun, Seung Pil, et al.
Publicado: (2018)

Advances on (+)-nootkatone microbial biosynthesis and its related enzymes
por: Li, Xiao, et al.
Publicado: (2021)

Tat-Fused Recombinant Human SAG Prevents Dopaminergic Neurodegeneration in a MPTP-Induced Parkinson’s Disease Model
por: Sohn, Eun Jeong, et al.
Publicado: (2014)

TFP5/TP5 peptide provides neuroprotection in the MPTP model of Parkinson's disease
por: Binukumar, BK, et al.
Publicado: (2016)

Anti-proliferative activity of A. Oxyphylla and its bioactive constituent nootkatone in colorectal cancer cells
por: Yoo, Eunsu, et al.
Publicado: (2020)

Lonchocarpine Increases Nrf2/ARE-Mediated Antioxidant Enzyme Expression by Modulating AMPK and MAPK Signaling in Brain Astrocytes
por: Jeong, Yeon-Hui, et al.
Publicado: (2016)

α7 nicotinic acetylcholine receptor-mediated neuroprotection against dopaminergic neuron loss in an MPTP mouse model via inhibition of astrocyte activation
por: Liu, Yuan, et al.
Publicado: (2012)

The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson’s Disease
por: Haque, Md Ezazul, et al.
Publicado: (2021)

Anti-inflammatory and anti-oxidant mechanisms of an MMP-8 inhibitor in lipoteichoic acid-stimulated rat primary astrocytes: involvement of NF-κB, Nrf2, and PPAR-γ signaling pathways
por: Lee, Eun-Jung, et al.
Publicado: (2018)

Remote tissue conditioning is neuroprotective against MPTP insult in mice
por: Kim, Boaz, et al.
Publicado: (2018)

Low dose pramipexole is neuroprotective in the MPTP mouse model of Parkinson's disease, and downregulates the dopamine transporter via the D(3 )receptor
por: Joyce, Jeffrey N, et al.
Publicado: (2004)

Astrocytes, Microglia, and Parkinson's Disease
por: Joe, Eun-Hye, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ac0us38vv4951shtsnpi8lpjo4