Cargando…
Amyloid β-Oligomers Inhibit the Nuclear Ca(2+) Signals and the Neuroprotective Gene Expression Induced by Gabazine in Hippocampal Neurons
Hippocampal neuronal activity generates dendritic and somatic Ca(2+) signals, which, depending on stimulus intensity, rapidly propagate to the nucleus and induce the expression of transcription factors and genes with crucial roles in cognitive functions. Soluble amyloid-beta oligomers (AβOs), the ma...
Autores principales: | Lobos, Pedro, Vega-Vásquez, Ignacio, Bruna, Barbara, Gleitze, Silvia, Toledo, Jorge, Härtel, Steffen, Hidalgo, Cecilia, Paula-Lima, Andrea |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669355/ https://www.ncbi.nlm.nih.gov/pubmed/38001825 http://dx.doi.org/10.3390/antiox12111972 |
Ejemplares similares
-
RyR2-Mediated Ca(2+) Release and Mitochondrial ROS Generation Partake in the Synaptic Dysfunction Caused by Amyloid β Peptide Oligomers
por: SanMartín, Carol D., et al.
Publicado: (2017) -
Ryanodine Receptor Mediated Calcium Release Contributes to Ferroptosis Induced in Primary Hippocampal Neurons by GPX4 Inhibition
por: Gleitze, Silvia, et al.
Publicado: (2023) -
Astaxanthin Protects Primary Hippocampal Neurons against Noxious Effects of Aβ-Oligomers
por: Lobos, Pedro, et al.
Publicado: (2016) -
Structural insights into the interaction between gabazine (SR-95531) and Laodelphax striatellus GABA receptors
por: Fujie, Yuki, et al.
Publicado: (2022) -
Amyloid β-peptide oligomers, ryanodine receptor-mediated Ca(2+) release, and Wnt-5a/Ca(2+) signaling: opposing roles in neuronal mitochondrial dynamics?
por: Paula-Lima, Andrea C., et al.
Publicado: (2013)