Development of a Comprehensive Gene Signature Linking Hypoxia, Glycolysis, Lactylation, and Metabolomic Insights in Gastric Cancer through the Integration of Bulk and Single-Cell RNA-Seq Data

Background: Hypoxia and anaerobic glycolysis are cancer hallmarks and sources of the metabolite lactate. Intriguingly, lactate-induced protein lactylation is considered a novel epigenetic mechanism that predisposes cells toward a malignant state. However, the significance of comprehensive hypoxia–gl...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Xiangqian, Li, Yun, Chen, Yongheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669360/
https://www.ncbi.nlm.nih.gov/pubmed/38001949
http://dx.doi.org/10.3390/biomedicines11112948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669360/
https://www.ncbi.nlm.nih.gov/pubmed/38001949
http://dx.doi.org/10.3390/biomedicines11112948

Ejemplares similares