Prospection of Peptide Inhibitors of Thrombin from Diverse Origins Using a Machine Learning Pipeline

Thrombin is a key enzyme involved in the development and progression of many cardiovascular diseases. Direct thrombin inhibitors (DTIs), with their minimum off-target effects and immediacy of action, have greatly improved the treatment of these diseases. However, the risk of bleeding, pharmacokineti...

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Detalles Bibliográficos
Autores principales: Balakrishnan, Nivedha, Katkar, Rahul, Pham, Peter V., Downey, Taylor, Kashyap, Prarthna, Anastasiu, David C., Ramasubramanian, Anand K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669389/
https://www.ncbi.nlm.nih.gov/pubmed/38002424
http://dx.doi.org/10.3390/bioengineering10111300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669389/
https://www.ncbi.nlm.nih.gov/pubmed/38002424
http://dx.doi.org/10.3390/bioengineering10111300

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