Norlobaridone Inhibits Quorum Sensing-Dependent Biofilm Formation and Some Virulence Factors in Pseudomonas aeruginosa by Disrupting Its Transcriptional Activator Protein LasR Dimerization

In the present study, norlobaridone (NBD) was isolated from Parmotrema and then evaluated as a new potent quorum sensing (QS) inhibitor against Pseudomonas aeruginosa biofilm development. This phenolic natural product was found to reduce P. aeruginosa biofilm formation (64.6% inhibition) and its rel...

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Detalles Bibliográficos
Autores principales: Soltane, Raya, Alasiri, Ahlam, Taha, Mostafa N., Abd El-Aleam, Rehab H., Alghamdi, Kawthar Saad, Ghareeb, Mosad A., Keshek, Doaa El-Ghareeb, Cardoso, Susana M., Sayed, Ahmed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669572/
https://www.ncbi.nlm.nih.gov/pubmed/38002255
http://dx.doi.org/10.3390/biom13111573

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669572/
https://www.ncbi.nlm.nih.gov/pubmed/38002255
http://dx.doi.org/10.3390/biom13111573

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