Dopamine-Depleted Dopamine Transporter Knockout (DDD) Mice: Dyskinesia with L-DOPA and Dopamine D1 Agonists

L-DOPA is the mainstay of treatment for Parkinson’s disease (PD). However, over time this drug can produce dyskinesia. A useful acute PD model for screening novel compounds for anti-parkinsonian and L-DOPA-induced dyskinesia (LID) are dopamine-depleted dopamine-transporter KO (DDD) mice. Treatment w...

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Detalles Bibliográficos
Autores principales: Pogorelov, Vladimir M., Martini, Michael L., Jin, Jian, Wetsel, William C., Caron, Marc G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669682/
https://www.ncbi.nlm.nih.gov/pubmed/38002340
http://dx.doi.org/10.3390/biom13111658

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669682/
https://www.ncbi.nlm.nih.gov/pubmed/38002340
http://dx.doi.org/10.3390/biom13111658

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