Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal iron metabolism and elevated LIP levels are linked...

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Detalles Bibliográficos
Autores principales: Bayanbold, Khaliunaa, Singhania, Mekhla, Fath, Melissa A., Searby, Charles C., Stolwijk, Jeffrey M., Henrich, John B., Pulliam, Casey F., Schoenfeld, Joshua D., Mapuskar, Kranti A., Sho, Sei, Caster, Joseph M., Allen, Bryan G., Buettner, Garry R., Spies, Maria, Goswami, Prabhat C., Petronek, Michael S., Spitz, Douglas R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669787/
https://www.ncbi.nlm.nih.gov/pubmed/38001858
http://dx.doi.org/10.3390/antiox12112005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669787/
https://www.ncbi.nlm.nih.gov/pubmed/38001858
http://dx.doi.org/10.3390/antiox12112005

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