Pectolinarigenin Improves Oxidative Stress and Apoptosis in Mouse NSC-34 Motor Neuron Cell Lines Induced by C9-ALS-Associated Proline–Arginine Dipeptide Repeat Proteins by Enhancing Mitochondrial Fusion Mediated via the SIRT3/OPA1 Axis

Amyotrophic lateral sclerosis (ALS) is considered a fatal progressive degeneration of motor neurons (MN) caused by oxidative stress and mitochondrial dysfunction. There are currently no treatments available. The most common inherited form of ALS is the C9orf72 mutation (C9-ALS). The proline–arginine...

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Detalles Bibliográficos
Autor principal: Fu, Ru-Huei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669908/
https://www.ncbi.nlm.nih.gov/pubmed/38001861
http://dx.doi.org/10.3390/antiox12112008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669908/
https://www.ncbi.nlm.nih.gov/pubmed/38001861
http://dx.doi.org/10.3390/antiox12112008

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