Reduction in N-Acetylglucosaminyltransferase-I Activity Decreases Survivability and Delays Development of Zebrafish

A lack of complex and hybrid types of N-glycans in mice is embryonically lethal due to neural tube maldevelopment. N-acetylglucosaminyltransferase-I (GnT-I; Mgat1) catalyzes a required step for converting oligomannose N-glycans into hybrid and complex N-glycans. Unlike mice, zebrafish have two Mgat1...

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Detalles Bibliográficos
Autores principales: Hall, M. Kristen, Hatchett, Cody J., Shalygin, Sergei, Azadi, Parastoo, Schwalbe, Ruth A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669939/
https://www.ncbi.nlm.nih.gov/pubmed/37998752
http://dx.doi.org/10.3390/cimb45110575

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10669939/
https://www.ncbi.nlm.nih.gov/pubmed/37998752
http://dx.doi.org/10.3390/cimb45110575

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